Prospective GAE Trial

A Prospective Single-Arm Trial of Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: Clinical and Biomarker Outcomes

🔍 **Clinical Question:**  

What are the longitudinal effects of genicular artery embolization (GAE) on biomarkers implicated in knee osteoarthritis (KOA) pathogenesis?

💡 **Key Insight:**  

Genicular artery embolization (GAE) provided significant and sustained clinical improvements in patients with symptomatic knee osteoarthritis.

GAE demonstrated a favorable safety profile, with adverse events being predominantly mild and transient.

GAE was associated with a significant reduction in key inflammatory and angiogenic biomarkers (vascular endothelial growth factor and interleukin-1 receptor antagonist) at 12 months.

👉 **Why it matters:**  

GAE is a safe treatment for symptomatic KOA, providing clinically significant pain relief for a subset of patients. The observed reductions in serum VEGF and IL-1Ra levels following GAE may contribute to local pain relief and decreased inflammation in the knee joints.

➡️ **Full Article:** 

https://doi.org/10.1016/j.jvir.2025.08.009

#InterventionalRadiology #MSKIR #GAE #OA #MedEd