Wednesday, October 25, 2023

A Review of Materials and Medications with Religious or Dietary Significance in the Interventional Radiology Suite

A Review of Materials and Medications with Religious or Dietary Significance in the Interventional Radiology Suite


Clinical Question


How can appropriate holistic considerations be implemented in a patient-centered care when incorporating different medications and medical devices with culturally or religiously sensitive ingredients in an interventional radiology suite?

Take Away Point


Different religions and cultures have different sets of restrictions with regards to specific sensitive ingredients present in appropriate medications or devices. This provides a spectrum of challenges depending on what the respective culture/religion allows or what it is willing to tolerate in specific scenarios which may prompt a necessary conversation between the physician and the patient.

Reference


Wilson R, Hu Z, Cormac O’Brien, Meer E, Agarwal A, Murray T. A Review of Materials and Medications with Religious or Dietary Significance in the Interventional Radiology Suite. Journal of Vascular and Interventional Radiology. 2023;34(10):1717-1721. doi:https://doi.org/10.1016/j.jvir.2023.06.035

click here for abstract


Study Design


Social Science Study

Funding Source


No reported funding

Setting


Academic, St. Paul’s Hospital, Vancouver, British Columbia, Canada
Academic, University of British Columbia, Vancouver, British Columbia, Canada
Academic, Schooland School of Medicine, Kingston, Ontario, Canada

Table 1.Dietary Restrictions of Specific Religions
ReligionSpecific restriction
ChristianitySome denominations have specific restrictions during Lent or choose to forgo animal products and ethanol. Certain weekdays or holy days may also preclude meat/dairy consumption.
Jehovah’s Witnesses (Christian Denomination)Avoid blood products (ie, blood transfusions).
Seventh-day Adventist (Christian Denomination)Some choose to refrain from consuming animal products (excluding eggs).
JudaismStrict followers may only consume kosher products.
All porcine and shellfish products are prohibited.
Land animals consumed must be mammals that chew their cud and have cloven hooves.
Birds of prey are prohibited.
IslamStrict followers may only consume animal products obtained through ritualistic method (halal).
Porcine products and ethanol are prohibited.
HinduismMajority of followers are vegetarian and abstain from all animal products, including eggs.
Those who are not vegetarian still abstain from bovine and porcine products, along with ethanol.
BuddhismNo universal restrictions.
Those who are vegetarian refrain from consuming all animal products, including eggs.
SikhismDietary restrictions are an individual choice.
Those who are vegetarian refrain from consuming all animal products, including eggs.
Those who are not vegetarian may abstain from consuming bovine and porcine products, along with ethanol.
All products obtained from other religious guidelines (halal, kosher) are prohibited.
VeganismAll animal products, including eggs, are prohibited.


Figure


Table 1: Brief summary of different common religions/cultures and their associated restrictions


Summary


Globalization has exposed people to a wide variety of approaches to life dependent on personal and religious preferences. These different sets of practices implement specific restrictions and permissions which ultimately impact the decision one makes in his or her daily life. One of those specific sets of restrictions is the avoidance of certain animal-derived products which differ from practice to practice but are well-known ingredients in certain medications and medical devices.

The article briefly details consumptive restrictions and conditions that exist in major denominations of secular or religious groups. Afterwards the topic of autonomy is then brought forth, which the article alludes to as the basis for the potential need for this discussion. Specifically, competent patients have the right to make informed decisions, and part of the information that would help them impact their decision-making involves religiously or culturally sensitive ingredients that make up certain medications or devices. One proposed method is preprocedural screening flagging patients with relevant restrictions to animal-derived products.

Despite the important holistic consideration outlining sensitive ingredients would provide, there are multiple challenges. Firstly, the specific and even the magnitude of certain restrictions not only differ from religion to religion, but even amongst different sects of a particular religion. This makes it difficult to completely standardize restrictions for any one particular group. Secondly, new medications and devices are introduced at a high rate, further compounding the challenge of keeping a comprehensive list of all sensitive products to inform specific patients with.

Commentary


The authors in this study explored the prospect of culturally or religiously sensitive animal-derived products and the challenges that come with either informing patients appropriately or being up-to-date with all of them in the medical devices or medications. While autonomy is one of the central tenets of medicine and serves as the basis for justification of informing patients of culturally or religiously sensitive ingredients, the article explains why this is severely challenging.

Firstly, for the most part most, if not all, of the major world religions do not have an entire group agreeing on the specific details pertaining to permission or restrictions. For example, the article referenced how Muslims avoid porcine products, but the concept and application of “Dharurah,” which involves how certain forbidden products become permissible in the context of life-saving situations is not necessarily entirely agreed upon amongst all schools of thought in the Islamic scholarship. Thus, even if a physician were to meet a Muslim patient and were to inform them about a product, there is no guarantee that the patient follows a specific school of thought that would otherwise ameliorate options presented to him or her.

Secondly, with the rapidity of new medications and medical devices introduced to the market over time, it is nearly impossible to keep a comprehensive list of all the ingredients that may be present in such facets, even if the financial and other costs of such task were feasible.

These challenges brought forth explain why I do not have a perfect solution for addressing this challenge, even though this can significantly improve the holistic approach physicians can bring to their patients. However, were this to be successfully implemented, this can significantly improve the holistic care model brought about upon the patients.

Post author:
Naeem Patel, DO
Radiology Resident, PGY4
Department of Radiology, Interventional Radiology Division
Hartford Hospital, Hartford, CT
@Naeemp7Patel

Tuesday, October 24, 2023

Evaluation of an Artificial Intelligence Chatbot for Delivery of IR Patient Education Material: A Comparison with Societal Website Content

Evaluation of an Artificial Intelligence Chatbot for Delivery of IR Patient Education Material: A Comparison with Societal Website Content


Clinical question

How does the completeness, accuracy and reliability of a large language chatbot model as a tool for patient education in the field of interventional radiology compare to a traditional societal website.


Take away point

While employing a large language chatbot model for patient education in interventional radiology shows promise, it also has limitations. Readers should be aware that while the chatbot's responses are generally thorough and factual, they can occasionally be incomplete or incorrect. Additionally, content provided by ChatGPT was found to be longer and more difficult to read when compared to a traditional societal website. As of now, patients and providers should be cautious when relying solely on chatbot generated content and consider augmenting it with other trusted sources.


Reference

McCarthy CJ, Berkowitz S, Ramalingam V, Ahmed M. Evaluation of an Artificial Intelligence Chatbot for Delivery of IR Patient Education Material: A Comparison with Societal Website Content. J Vasc Interv Radiol. 2023 Oct;34(10):1760-1768.e32. doi: 10.1016/j.jvir.2023.05.037. Epub 2023 Jun 16. PMID: 37330210.

Click here for abstract

Study design

Artificial intelligence study.

Funding Source

No reported funding.


Setting

Not explicitly mentioned.



Figure

Summary of Patient Education Materials Assessment Tool for Printable Materials (PEMAT-P) scores

Summary


The study involved analyzing 104 questions posed to ChatGPT and comparing its responses to content from the Society of Interventional Radiology Patient Center website. The goal was to assess whether ChatGPT could effectively serve as a resource for patient education in the field of interventional radiology. Readability was assessed using five validated scales, and understandability and actionability were evaluated using the Patient Education Materials Assessment Tool for Printable Materials (PEMAT-P).

ChatGPT generally provided longer and more complex responses compared to the website. Additionally, chatbot generated content was found to be more challenging to read and nearly one grade level above the comparison. Surprisingly, content from both models was written at a higher grade level than recommended for patient education materials. The study also revealed that while uncommon, ChatGPT could provide incomplete or inaccurate information.

Most importantly, the study highlighted both the potential and limitations of utilizing current chatbots for patient education in the field of interventional radiology. Concerns were raised about the chatbot's tendency to provide verbose responses and guess answers when faced with ambiguous questions. The authors suggested that ChatGPT and similar chatbot models hold promise as patient education tools while underscoring the importance of improvements in accuracy and readability through customization.

Commentary


The study addresses an important and relevant clinical question while providing valuable insights into the challenges and limitations of using AI chatbots for patient education. This technology remains new to the general public, and this study may serve as a starting point for ongoing research in this field as transformative changes occur. Future research could involve a larger pool of reviewers to assess accuracy, reassess after adding visual aids to patient education, and propose solutions for optimizing and improving AI-driven patient education content.

Post Author:
Ryan R. Babayev, MD, MSc
Diagnostic Radiology Resident
Hartford Hospital
@RyanBabayevMD

Wednesday, September 6, 2023

An Interim Analysis of the First 102 Patients Treated in the Prospective Vertebral Augmentation Sacroplasty Fracture Registry

An Interim Analysis of the First 102 Patients Treated in the Prospective Vertebral Augmentation Sacroplasty Fracture Registry


Clinical question

Is sacroplasty an effective and safe procedure for reducing pain and improving function in the treatment of patients with sacral insufficiency fractures?

Take away point

Sacroplasty effectively and safely reduced painful sacral insufficiency fractures while maintaining patient-reported outcomes over 6 months.

Reference

An Interim Analysis of the First 102 Patients Treated in the Prospective Vertebral Augmentation Sacroplasty Fracture Registry. Beall D. P et al. Journal of Vascular and Interventional Radiology, Volume 34, Issue 9, 1477 – 1484. doi.org/10.1016/j.jvir.2023.05.024

Click here for the abstract

Study design

Multicenter, prospective, single-arm registry.


Funding Source

D.P.B. reports compensation from Medtronic related to consultancy, research, and teaching; grants from Benvenue, Alphatech Spine, Medical Metrics, Liventa, Vexim, and Mesoblast; grants and personal fees from Medtronic, Halyard, Vivex, and Vertiflex; consultancy fees from Dfine and Osseon; and other from Lilly, Smith & Nephew, Biomet, Vertiflex, Synthes, and Integral Spine Solutions. N.H.S. reports compensation related to royalties from Globus and consulting, research, and teaching from Medtronic.


Setting

10 sites in the United States consisting of small community practices, radiology group practices, multispecialty group practices, and large academic medical centers.






Figure 2


Mean Numerical Rating Scale scores at the 1-, 3-, and 6-month time points.

Summary


    Sacral insufficiency fractures (SIFs) are painful fractures of the sacrum that can occur in patients with osteoporosis or neoplastic involvement. These fractures often go undiagnosed and are a common source of low back pain in elderly patients. Sacroplasty has been shown to be an effective and safe treatment for sacral fractures with minimal adverse effects. However, no prospective observational trials (registries) have reported basic safety and efficacy data. The authors performed a multicenter, prospective, single-arm registry study with 102 patients to assess the efficacy and safety of sacroplasty for the treatment of sacral insufficiency fractures.

    The study included 102 patients presenting with SIF. Patient-reported outcome (PRO) data was collected via phone call surveys at the 1-, 3-, and 6-month mark after the initial sacroplasty procedure. The PROs obtained included pain, assessed using the Numerical Rating Scale (NRS), and function, assessed using the Roland-Morris Disability Questionnaire (RMDQ). The minimal clinically important difference was defined as a change of greater than or equal to 2 points from baseline on the NRS for pain and greater than or equal to 5 points from baseline on the RMDQ for function. The secondary endpoints were cement leakage, adverse effects, hospital readmission, new neurologic deficits, and death.

    Patients were analyzed using frequencies for categorical variables and means for continuous variables, while PROs were reported at baseline, 1, 3, and 6 months. Generalized estimating equation models were used to analyze the effects of time on repeated measurements for pain and function. Post hoc tests with Bonferroni adjustments were used to compare the mean differences between PROs.

    The most common treated levels were both S1 and S2, and prior to cement augmentation, nonsurgical management was attempted in 93.1% of the patients, and 78.4% of patients with sacral fractures had an osteoporosis diagnosis. The study demonstrated statistically significant (P < .001) improvements in NRS and RMDQ scores at 6 months compared to baseline. Mean RMDQ scores decreased from 17.7 to 5.2 over a 6-month period and mean NRS scores decreased from 7.8 to 0.9 over the same period. Out of the 102 patients, only one experienced an adverse effect of cement extravasation leading to new neurologic deficits. Cement leakage was observed in 17.7% of the patients but remained asymptomatic except for one patient with new-onset neurological deficits. There were no patient deaths, and hospital readmission after sacroplasty occurred in 8 of the 102 patients (7.8%) at 6 months and one patient each after 1 and 3 months.

Commentary


    The purpose of the study was to provide prospective observational data on the efficacy and safety of sacroplasty for treating sacral insufficiency fractures using patient-reported outcomes. The study used a prospective registry approach, enabling the collection of real-world data from a diverse patient population across the United States. Considering the inherent limitations of a registry study the methods and study approach was well-structured. The statistical model and equation models used to analyze the data appear to be appropriate. However, the study does not provide further detail on the statistical analysis process. The presented outcomes are convincing, indicating significant improvements in pain and function following sacroplasty in SIF patients. The study’s results align with data from previous studies and meta-analyses. Areas of improvement include a clearer explanation of the statistical analyses and independent radiographic evaluations of patients. Overall, the paper provides compelling evidence that support the safety and efficacy of sacroplasty for patients with SIF.

Post author

Aric Patel, MS
University of New England College of Osteopathic Medicine